2021-22 NFL Week 16: San Francisco 49ers vs. Tennessee Titans December 23, 2020 by Marc Jerbs

On Thursday, the San Francisco 49ers will face the Tennessee Titans in Week 16 of the 2021-22 NFL season.

Kick-off is set 8:20PM EST at the Nissan Stadium in Nashville, TN.

Playoff positioning is at stake for both teams.

The Tennessee Titans currently lead the AFC South and enter Week 16 as the No. 3 seed in the AFC.

Tennessee's tough schedule took a toll on the team as they drop three of their last four games.

They will return home to host the 49ers and their fans will rejuvenate them during the game.

The San Francisco 49ers two-game winning streak has put themselves at 3rd place in the NFC West.

With their record, they are No.6 in the NFC.

Seven teams will make the playoffs this season in each conference.

Expect the 49ers to capitalize if the Titans' turnovers and interceptions continues.

The sportsbook handicappers have installed the San Francisco 49ers as the favorites to win over the Tennessee Titans on Thursday night.