2025-26 NFL Week 5 Preview - SF vs. LAR: Can the 49ers bounce back against the Rams on Thursday? October 2, 2025 by Marc Jerbs

The San Francisco 49ers and Los Angeles Rams will face off in a pivotal Week 5 matchup on Thursday, October 2, 2025. Kickoff is scheduled 8:15 PM Eastern Daylight Time (EDT) at SoFi Stadium in Inglewood, California. This prime-time showdown not only highlights one of the NFL's most historic rivalries but could also have major implications in the NFC West race.

San Francisco 49ers Season Overview

The 49ers are coming off their first defeat of the season in Week 4, falling 26-21 to the Jacksonville Jaguars. Through four games, they have scored 80 points (20.0 per game, ranking 23rd in the league) while allowing just 75 points (18.8 per game, 7th overall). Their record against the spread sits at 2-2-0.

Offensive Output:

San Francisco has produced 1,472 total yards of offense, with 1,120 passing yards and 352 rushing yards. The unit has tallied 8 passing touchdowns but has yet to record a rushing score.

• Passing Leaders: Brock Purdy has completed 48 of 73 passes (65.8%) for 586 yards, 4 touchdowns, and 2 interceptions in two games. Mac Jones has added 563 yards and 4 touchdowns with a 66.3% completion rate.
• Rushing Leaders: Christian McCaffrey leads with 225 yards on 69 carries (3.3 yards per attempt), while Brian Robinson Jr. has chipped in 96 yards on 22 attempts.
• Receiving Leaders: Ricky Pearsall has 20 receptions for 327 yards, while Jauan Jennings has 129 yards and 1 touchdown. McCaffrey continues to shine as a dual threat, adding 305 receiving yards and 2 scores.
• Defensive Leaders: Fred Warner anchors the defense with 38 tackles, Dee Winters follows with 32, and Nick Bosa has recorded 2.0 sacks with 4 tackles for loss.

San Francisco 49ers vs. Los Angeles Rams Sports Bet Odds

The Rams are the favorites to win the game. Here are our latest odds:

• The Rams are favored by 7.5 points, with a money line of -370.
• The 49ers are the underdogs by 7.5 points, with a money line of +296.
• The Total is set at 45.5 points, with the over at -110 and the under at -110.

Los Angeles Rams Season Overview

The Rams enter Week 5 with a 3-1 record under head coach Sean McVay. Their offense has scored 100 points this season, averaging 25.0 per game (13th in the league), while the defense has allowed 81 points (20.3 per game, 10th overall).

Offensive Lineup:

Matthew Stafford leads the attack with Kyren Williams at running back, supported by wide receivers Puka Nacua, Davante Adams, Jordan Whittington, and tight end Tyler Higbee.

Defensive Leaders:

Ernest Jones tops the Rams' defense with 35 tackles, while Christian Rozeboom has 27. Aaron Donald remains a dominant force, recording 23 tackles and 5 sacks. Other key defenders include Byron Young, Jared Verse, Nate Landman, Braden Fiske, and Kobie Turner.

Injury Reports

San Francisco 49ers:
The 49ers are facing a wave of injuries, most notably QB Brock Purdy, WR Ricky Pearsall, and WR Jauan Jennings all being sidelined. Christian McCaffrey, Brandon Aiyuk, and multiple defensive contributors remain questionable.

Los Angeles Rams:
The Rams also face injury challenges, with TE Tyler Higbee and OG Rob Havenstein listed as doubtful. However, Colby Parkinson, Steve Avila, and Kamren Kinchens all returned to full practice ahead of Thursday's game.

Historical Matchups

The 49ers and Rams have squared off 152 times, with San Francisco leading the all-time series 78-71-3. While Los Angeles once held a dominant edge, San Francisco surged during the 1980s and 1990s to take control of the rivalry.

In recent years, the 49ers have won 7 of the last 10 regular-season meetings. However, the Rams have claimed the last three, including a 12-6 victory on December 12, 2024. Each of those wins came by narrow margins of one, three, and six points, underscoring how competitive this matchup remains.

Final Thought

Thursday Night Football in Week 5 brings another chapter of the storied 49ers–Rams rivalry. San Francisco is eager to rebound after their first setback of the season, while Los Angeles looks to continue its momentum and extend its winning streak in the series. With both teams battling injuries and the NFC West standings still wide open, expect a high-intensity prime-time contest that could swing early-season momentum in either direction.

2025-26 San Francisco 49ers vs. Los Angeles Rams Team Stats

SAN FRANCISCO 49ers	VS	LOS ANGELES RAMS
T-1st NFC West (3-1) Away (2-0) | STRK L1	Standings	T-1st NFC West (3-1) Home (2-0) | STRK W1
280.0	Passing Yards Per Game	388.3
88.0	Rushing Yards Per Game	267.5
20.0	Points Per Game	25.0
165.0	Passing Yards Allowed Per Game	186.0
115.5	Rushing Yards Allowed Per Game	98.5